α-Cyano-4-hydroxycinnamic acid(α-CHCA)

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

α-Cyano-4-羟基肉桂酸 (α-CHCA) 是单羧酸转运蛋白 1 (MCT1) 的抑制剂，可阻断大鼠心脏线粒体中的丙酮酸转运 (IC50 : 1.5 μM)。

α-Cyano-4-hydroxycinnamic acid (α-CHCA) is an inhibitor of monocarboxylate transporter 1 (MCT1) that blocks pyruvate transport in rat heart mitochondria (IC50 : 1.5 μM).

α-Cyano-4-hydroxycinnamic acid (α-Cyano-4-hydroxycinnamate) inhibits monocarboxylates transport such as lactate and pyruvate. α-Cyano-4-hydroxycinnamic acid (CHC; 0.5 mM and 1 mM) of 1 mM has a significant inhibitory effect on branching morphogenesis and decreases the epithelial perimeter and area of lung explants in a dose dependent way. ?At 100 μM concentration, α-Cyano-4-hydroxycinnamic acid rapidly and almost totally inhibits O2 uptake by rat heart mitochondria oxidizing pyruvate. Inhibition can be detected at concentrations of inhibitor as low as 1 μM although inhibition took time to develop at this concentration.

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Membrane Transporter/Ion Channel

Monocarboxylate Transporter

MCT

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28166-41-8

189.17

C10H7NO3

>98% (HPLC)

DMSO:37mg/mL(195.59mM)

N#C/C(=C\c1ccc(O)cc1)C(=O)O

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(-20℃)

With Ice Pack

≥ 2 years